De-SUMOylation of CTCF in Hypoxic Stress-induced Human Corneal Epithelial Cells
نویسندگان
چکیده
*Address correspondence to: Luo Lu, Department of Medicine, David Geffen School of Medicine at UCLA, 1124 W. Carson St., H-H Bldg., Torrance, CA 90502; Tel. (310) 781-1404; Fax. (310) 781-9065; E-mail: [email protected] Capsule Background: CTCF plays important roles in the epigenetic control of cell fate. Results: Hypoxic stress suppressed a higher MW form of CTCF by de-SUMOylation associated with lysine 74 and lysine 689 residues, resulting in significantly inhibited Pax6 expression. Conclusion: Hypoxic stress induces de-SUMOylation of CTCF to functionally regulate CTCF activity. Significance: CTCF plays important roles in growth factor/stress-regulated cell fates through post-translational modulation to control gene expression.
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Epigenetic factor CTCF (CCCTC binding factor) plays important roles in genetic controls of the cell fate. Previous studies found in corneal epithelial cells that CTCF is regulated by epidermal growth factor (EGF) through activation of NF-κB p65/p50. It also found that CTCF is suppressed in ultraviolet (UV) stress-induced corneal epithelial cells. However, it is still unknown how UV stress down-...
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